Animal Models of Neurological Disorders

Large animal models of neurological disorders for gene therapy.

he development of therapeutic interventions for genetic disorders and diseases that affect the central nervous system (CNS) has proven challenging. There has been significant progress in the development of gene therapy strategies in murine models of human disease, but gene therapy outcomes in these models do not always translate to the human setting. Therefore, large animal models are crucial t...

Editorial: Reelin-Related Neurological Disorders and Animal Models

Homozygous, loss-of-function mutations in the mouse Reelin gene cause a severe neurological phenotype known as reeler. These mutant mice exhibit marked cerebellar hypoplasia, dyslamination of cortical and hippocampal cellular layers, and malposition of specific neuronal populations in the brain stem and spinal cord. Similarly, homozygous mutations in the very conserved human REELIN gene cause a...

Amygdalar Models of Neurological and Neuropsychiatric Disorders

Teaching neurophysiology, neuropharmacology, and experimental design using animal models of psychiatric and neurological disorders.

Animal models have been widely used for studying the physiology and pharmacology of psychiatric and neurological diseases. The concepts of face, construct, and predictive validity are used as indicators to estimate the extent to which the animal model mimics the disease. Currently, we used these three concepts to design a theoretical assignment to integrate the teaching of neurophysiology, neur...

Animal Models of Eating Disorders: Hypothalamic Function

INTRODUCTION 0 ne of the oldest and most investigated models of food intake disorders is the hyperphagia response to electrical stimulation of the lateral hypothalamic area (ESLH) in sated animals [1]. For decades researchers have been concerned with the possibility that under natural conditions, individual differences in the level of activity of neurons in the LH could override other mechanism...